MiRNAs: Dynamic regulators of immune cell functions in inflammation and cancer

MicroRNAs (miRNAs), small noncoding RNA molecules, have emerged as important regulators of almost all cellular processes. By binding to specific sequence motifs within the 3 ´- untranslated region of their target mRNAs, they induce either mRNA degradation or translational repression. In the human immune system, potent miRNAs and miRNA-clusters have been discovered, that exert pivotal roles in the regulation of gene expression. By targeting cellular signaling hubs, thes e so-called immuno-miRs have fundamental regulative impact on both innate and adaptive immune cells in health and disease.

Source: Cancer Letters - May 22, 2018 Category: Cancer & Oncology Authors: Simon Hirschberger, Ludwig Christian Hinske, Simone Kreth Tags: Mini-review Source Type: research