Preservation of type H vessels and osteoblasts by enhanced preosteoclast platelet-derived growth factor type BB attenuates glucocorticoid-induced osteoporosis in growing mice

Survival of chronic diseases in childhood is often achieved utilizing glucocorticoids, but comes with significant side effects, including glucocorticoid-induced osteoporosis (GIO). Knowledge of the mechanism of GIO is limited to the adult skeleton. We explored the effect of genetic loss and inhibition of cathepsin K (Ctsk) as a potential treatment target in a young GIO mouse model as genetic loss of cathepsin K results in a mild form of osteopetrosis secondary to impaired osteoclast bone resorption with maintenance of bone formation.

Source: Bone - May 22, 2018 Category: Orthopaedics Authors: Ping Yang, Shan Lv, Yan Wang, Yi Peng, Zixing Ye, Zhuying Xia, Guoxian Ding, Xu Cao, Janet L. Crane Tags: Full Length Article Source Type: research