From traditional biochemical signals to molecular markers for detection of sepsis after burn injuries

Following a severe burn injury, the body must respond immediately to activate the immune system in order to challenge the insult and to restore homeostasis while also preventing any bacteria from establishing an infection [1]. However, burns can leave skin and other tissues vulnerable to bacterial infection and increase the risk of sepsis (Fig. 1A). Sepsis is defined as life-threatening organ dysfunction [2 –4] caused by a dysregulated host response to infection [5]. This process is regarded as a major public-health concern, with the mortality rate, depending on the severity of the insult, ranging from 30 to 50% [6].
Source: Burns : Journal of the International Society for Burn Injuries - Category: Cosmetic Surgery Authors: Tags: Review Source Type: research