Conference Abstracts: CMR2013

CONCLUSIONSWe describe a simple preparation of peptide‐decorated microbubbles, contrast agents for ultrasound imaging, and their successful targeting in vitro (adhesion to receptor‐coated surfaces) and in vivo, in a subcutaneous murine tumor model.FINANCIAL INTEREST STATEMENTThe authors do have a direct or indirect financial interest in the products under investigation or subject matter discussed in the manuscript: A. Klibanov is a co‐founder and minority shareholder of Targeson Inc., a startup developing targeted ultrasound contrast for preclinical use (Targeson is not involved in this study in any way and unaware of it at the time of submission of this abstract). The authors grant permission to publish this information or an appropriate summary thereof with the abstract.REFERENCES1. Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R. Noninvasive vascular cell adhesion molecule‐1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation 2006;114(14):1504–1511.2. Southworth R, Kaneda M, Chen J, Zhang L, Zhang H, Yang X, Razavi R, Lanza G, Wickline SA. Renal vascular inflammation induced by Western diet in ApoE‐null mice quantified by (19)F NMR of VCAM‐1 targeted nanobeacons. Nanomedicine 2009;5(3):359–367.3. Starzec A, Ladam P, Vassy R, Badache S, Bouchemal N, Navaza A, du Penhoat CH, Perret GY. Structure‐function analysis of the antiangiogenic AT...
Source: Contrast Media and Molecular Imaging - Category: Radiology Tags: Abstracts Source Type: research