Defining osteoblast and adipocyte lineages in the bone marrow
Bone is a complex endocrine organ that facilitates structural support, protection to vital organs, sites for hematopoiesis, and calcium homeostasis. The bone marrow microenvironment is a heterogeneous niche consisting of multipotent musculoskeletal and hematopoietic progenitors and their derivative terminal cell types. Amongst these progenitors, bone marrow mesenchymal stem/stromal cells (BMSCs) may differentiate into osteogenic, adipogenic, myogenic, and chondrogenic lineages to support musculoskeletal development as well as tissue homeostasis, regeneration and repair during adulthood.
Source: Bone - Category: Orthopaedics Authors: J.L. Pierce, D.L. Begun, J.J. Westendorf, M.E. McGee-Lawrence Tags: Full Length Article Source Type: research