in vitro activity of Oritavancin against biofilms of staphylococci isolated from prosthetic joint infection

We tested the in vitro activity of oritavancin against 185 staphylococci associated with prosthetic joint infection (PJI), including 37 methicillin-resistant S. aureus (MRSA), 67 methicillin-susceptible S. aureus (MSSA), 59 methicillin-resistant S. epidermidis (MRSE) and 22 methicillin-susceptible S. epidermidis (MSSE) isolates. The oritavancin MIC50 for S. aureus and MSSE was 0.03 μg/mL, and for MRSE was 0.06μg/mL; MIC90 for S. aureus and S. epidermidis was 0.12μg/mL for both the methicillin-resistant and -susceptible subgroups.
Source: Diagnostic Microbiology and Infectious Disease - Category: Microbiology Authors: Source Type: research