LncTIC1 interacts with β-catenin to drive liver TIC self-renewal and liver tumorigenesis

Liver tumor-initiating cells (TICs) are drivers of liver tumorigenesis, and Wnt/ β-catenin activation plays a principal role in the self-renewal of liver TICs. Despite a deep understanding of Wnt/β-catenin regulation, the roles of long noncoding RNAs (lncRNAs) in Wnt/β-catenin activation and liver TIC self-renewal are largely unknown. Here, we performed unbiased screening of lncRNAs in liver tumorigenesis and found lncTIC1 was highly expressed with liver tumorigenesis. LncTIC1 was also highly expressed in liver TICs and required for the self-renewal of liver TICs.

Source: Cancer Letters - May 17, 2018 Category: Cancer & Oncology Authors: Zhenzhen Chen, Lintong Yao, Yating Liu, Pingping Zhu Tags: Original Articles Source Type: research