Neuregulin 1 (NRG1) gene expression predicts functional outcomes in individuals at clinical high-risk for psychosis

Psychosis is frequently preceded by a broad range of clinical symptoms with a marked decline in social and occupational function. (Schultze-Lutter et  al., 2015; Schultze-Lutter et al., 2012). Most of the high risk (HR) and ultra-high risk (UHR) studies to date have concentrated mainly on predicting transition to psychosis, but only a few studies have focused on the functional status and outcome of at-risk individuals. A meta-analysis showed th at at-risk individuals had a poor functioning and worse quality of life than healthy controls (Fusar-Poli et al., 2015).

Source: Psychiatry Research - May 17, 2018 Category: Psychiatry Authors: Vinita Jagannath, Miriam Gerstenberg, Susanne Walitza, Maurizia Franscini, Karsten Heekeren, Wulf R össler, Anastasia Theodoridou, Edna Grünblatt Source Type: research