Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis

Suppressing glutaminolysis does not always induce cancer cell death in glutamine dependent tumors because cells may switch to alternative energy sources. To reveal compensatory metabolic pathways, we investigated the metabolome-wide cellular response to inhibited glutaminolysis in cancer cells. Glutaminolysis inhibition with C.968 suppressed cell proliferation but was insufficient to induce cancer cell death. We found that lipid catabolism was activated as a compensation for glutaminolysis inhibition.

Source: Cancer Letters - May 17, 2018 Category: Cancer & Oncology Authors: Anna Halama, Michal Kulinski, Shaima S. Dib, Shaza B. Zaghlool, Kodappully S. Siveen, Ahmad Iskandarani, Jonas Zierer, Kirti S. Prabhu, Noothan J. Satheesh, Aditya M. Bhagwat, Shahab Uddin, Gabi Kastenm üller, Olivier Elemento, Steven S. Gross, Karsten S Tags: Original Articles Source Type: research