Neurological soft signs as a marker of cognitive impairment severity in people living with HIV

Since the introduction of Highly Active Antiretroviral Therapy (HAART), there has been a reduction in the incidence of HIV-associated Dementia (HAD), while the prevalence of milder forms of HIV-associated neurocognitive disorder (HAND) has increased. These mild forms of HAND are frequent conditions experienced by people living with HIV infection (PLWH) and could subsequently lead to HAD (Heaton et al., 2015). These disorders are important to understand, due to the central nervous system's (CNS) role as an HIV reservoir in persons who stay aviremic due to HAART (McArthur and Brew, 2010), and underlines the importance of early recognition of CNS involvement in PLWH.

Source: Psychiatry Research - May 17, 2018 Category: Psychiatry Authors: Pablo Toro, Mar ía Elena Ceballos, José Pesenti, María Inostroza, Daniela Valenzuela, Fernando Henríquez, Gonzalo Forno, Christina Herold, Johannes Schröder, Jorge Calderón Source Type: research