Chapter Eleven Linear Analogues of the Lipopeptide Battacin With Potent In Vitro Activity Against S. aureus

Publication date: 2018 Source:Advances in Protein Chemistry and Structural Biology, Volume 112 Author(s): Hugh D. Glossop, Esperanza Pearl, Gayan H. De Zoysa, Vijayalekshmi Sarojini Eight linear analogues of the lipopeptide battacin were evaluated for their antibacterial activity against the Gram-positive Staphylococcus aureus. Of this library, the enantiomeric lipopeptide analogue 9.4 exhibited nanomolar inhibitory activity (MIC=200nmol) against S. aureus. Furthermore, this lipopeptide was resilient toward degradation conditions when exposed to rat serum proteases for up to 8h.
Source: Advances in Protein Chemistry and Structural Biology - Category: Biochemistry Source Type: research