Antinuclear antibodies and cancer: A literature review

Antinuclear antibodies (ANAs) are a spectrum of autoantibodies that react with various nuclear and cytoplasmic components of normal human cells. The development of autoantibodies is the consequence of breakdown of immunologic tolerance, but their presence is not exclusive of autoimmune conditions. They are very important serological markers for different autoimmune disease, like connective tissue diseases (CTD) —eg, systemic lupus erythematosus (SLE), Sjögren’s syndrome (SS), scleroderma (SSc), polymyositis (PM), or mixed connective tissue disease (MCTD).
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research