Analytical performance of the Hologic Aptima HBV Quant Assay and the COBAS Ampliprep/COBAS TaqMan HBV test v2.0 for the quantification of HBV DNA in plasma samples

Hepatitis B virus (HBV) may cause chronic hepatitis B virus infection (CHB). The occurrence of CHB is dependent on the age of the individual acquiring infection [1]. The majority of infected adults achieves immune control of the infection and does not possess markers of active virus infection. In contrast, infection acquired perinatally or in early childhood often establishes CHB. CHB is associated with significant risk for development of liver failure and hepatocellular carcinoma and the risk for these complications is strongly associated with the levels of HBV DNA present in serum or plasma [2,3].
Source: Journal of Clinical Virology - Category: Virology Authors: Source Type: research