Pharmacokinetics –pharmacodynamics, computer decision support technologies, and antimicrobial stewardship: the compass and rudder

The first guidelines for conducting antimicrobial stewardship in the hospitalized setting were published in 2007. These guidelines recommend that stewardship programs employ the science of pharmacokinetics –pharmacodynamics (PK-PD) as well as adopting computerized decision support technologies when possible. The United States Food and Drug Administration have adopted PK-PD as a cornerstone in the evaluation of antimicrobial agents during clinical development. The core principles of PK-PD center arou nd describing the relationship between drug exposure indexed to the susceptibility of the infecting bacterial pathogen and patient response.
Source: Diagnostic Microbiology and Infectious Disease - Category: Microbiology Authors: Source Type: research