Effect of inhibin A on proliferation of porcine granulosa cells in  vitro

Inhibins regulate folliculogenesis, gametogenesis and hormone secretion via endocrine, paracrine and autocrine manners, and play roles in encouraging or suppressing proliferation of cells. In order to investigate the effects of inhibin A on proliferation and apoptosis of porcine granulosa cells (GCs), GCs were isolated from ovarian follicles (3 –6 mm), treated with inhibin A at different concentrations. The cell viability, mitochondrial membrane potential (MMP), expression of proliferation-related genes and cell cycle were detected.

Source: Theriogenology - March 26, 2018 Category: Genetics & Stem Cells Authors: Wanhong Li, Chunjin Li, Shuxiong Chen, Lina Sun, Hongjiao Li, Lu Chen, Xu Zhou Source Type: research