Simultaneous effects of IGF1 and Fadrozole on parthenogenesis and pluripotency markers in chicken embryo

So far, a synergistic effect was detected between insulin-like growth factor-I (IGF1) and anti-aromatase for sex reversal and pre-/post-natal growth of fertilized chicken embryo. Here, we hypothesized whether the growth and sexual female-to-male reversal effects of IGF1 and an anti-aromatase, Fadrozole, could improve the development of unfertilized, parthenogenetic chicken embryos. Simultaneous administration of IGF1 and Fadrozole increased the percentage of grade A embryos from 1.7% (no injection group) to 70.6%.

Source: Theriogenology - April 13, 2018 Category: Genetics & Stem Cells Authors: Zohreh Hajihoseini, Shahin Eghbalsaied Source Type: research