Load-Dependent Changes in Left Ventricular Structure and Function in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure [Original Articles]

Conclusions:
Hemodynamic unloading of a pathophysiologically relevant mouse model of HF results in normalization of LV structure, incomplete recovery of LV function, and incomplete reversal of the HF transcriptional program. The HF-DB mouse model may provide novel insights into mechanisms of reverse LV remodeling.

Source: Circulation: Heart Failure - May 1, 2018 Category: Cardiology Authors: Weinheimer, C. J., Kovacs, A., Evans, S., Matkovich, S. J., Barger, P. M., Mann, D. L. Tags: Contractile Function, Fibrosis, Hemodynamics, Cardiomyopathy, Remodeling Original Articles Source Type: research