IL-10 correlates with the expression of carboxypeptidase B2 and lymphovascular invasion in inflammatory breast cancer: The potential role of tumor infiltrated macrophages

Pro-carboxypeptidase B2 (pro-CPB2) or thrombin-activatable fibrinolysis inhibitor (TAFI) is a glycoprotein encoded by the CPB2 gene and deregulated in several cancer types, including breast cancer. Thrombin binding to thrombomodulin (TM), encoded by THBD, is important for TAFI activation. CPB2 gene expression is influenced by genetic polymorphism and cytok ines such as interleukin 10 (IL-10). Our previous results showed that tumor infiltrating monocytes/macrophages (CD14+/CD16+) isolated from inflammatory breast cancer (IBC) patients’ secrete high levels of IL-10.

Source: Current Problems in Cancer - January 10, 2018 Category: Cancer & Oncology Authors: Hossam Taha Mohamed, Noura El-Husseiny, Eslam A. El-Ghonaimy, Sherif Abdelaziz Ibrahim, Zainab A. Bazzi, Dora Cavallo-Medved, Michael B. Boffa, Mohamed El-Shinawi, Mona Mostafa Mohamed Source Type: research