Neural correlates of top-down regulation and generation of negative affect in major depressive disorder

Individuals with major depressive disorder (MDD) are impaired in regulating negative affect in two important ways: they have difficulty reducing negative emotions and they generate negative affect in the absence of external cues (Mathews  and MacLeod, 2005). Several neuroimaging studies investigating MDD-associated dysfunction in reducing negative affect have used tasks in which participants are asked to reappraise negative stimuli in order to alter their affective experience, typically to decrease negative affect (e.g., Ochsner e t al., 2012; Rive et al., 2013).

Source: Psychiatry Research: Neuroimaging - April 7, 2018 Category: Psychiatry Authors: Elena Goetz Davis, Lara C. Foland-Ross, Ian H. Gotlib Source Type: research