Comparison of thyroid transcription factor-1 expression by 2 monoclonal antibodies in schwannomas: the chosen clone matters

We have read with great interest the recently published study by Wang et al [1] on aberrant expression of thyroid transcription factor-1 (TTF-1) in schwannomas. The authors described nuclear TTF-1 in 109 (67.7%) schwannomas, including 102 of 132 (77.9%) conventional, 1 of 20 (5%) cellular, and 6 of 10 (60%) plexiform schwannomas. Nuclear staining was not identified in normal peripheral nerves and nonschwannoma peripheral nervous system lesions.

Source: Human Pathology - April 7, 2018 Category: Pathology Authors: David Creytens, Mieke Van Bockstal, Liesbeth Ferdinande, Jo Van Dorpe Tags: Correspondence Source Type: research