Ceftolozane/tazobactam sensitivity patterns in Pseudomonas aeruginosa isolates recovered from sputum of cystic fibrosis patients

Ceftolozane/tazobactam is a combination intravenous antibiotic with potentially important activity against drug resistant Gram negative organisms. Ceftolozane/tazobactam's in vitro activity was evaluated in 30 samples collected from 23 adult cystic fibrosis patients with extended and pan-resistant Pseudomonas aeruginosa (PSAR) in 2015. Testing results demonstrated that 30% of the isolates were susceptible,13% were intermediate, and 57% were resistant. This suggests that ceftolozane/tazobactam may be a useful antibiotic in carefully selected, multi-drug resistant Pseudomonas isolates.
Source: Diagnostic Microbiology and Infectious Disease - Category: Microbiology Authors: Tags: Note Source Type: research