CDK1 inhibition facilitates formation of syncytiotrophoblasts and expression of human Chorionic Gonadotropin

The human placental syncytiotrophoblast (STB) cells play essential roles in embryo implantation and nutrient exchange between the mother and the fetus. STBs are polyploid which are formed by fusion of diploid cytotrophoblast (CTB) cells. Abnormality in STBs formation can result in pregnancy-related disorders. While a number of genes have been associated with CTB fusion the initial events that trigger cell fusion are not well understood. Primary objective of this study was to enhance our understanding about the molecular mechanism of placental cell fusion.

Source: Placenta - May 11, 2018 Category: Reproduction Medicine Authors: Rahim Ullah, Saira Dar, Tanvir Ahmad, Christelle de Renty, Mohammad Usman, Melvin L. DePamphilis, Amir Faisal, Syed Shahzad-ul-Hussan, Zakir Ullah Source Type: research