Early TGF- β inhibition in mice reduces the incidence of breast cancer induced bone disease in a myeloid dependent manner

The tumor-cell microenvironment is recognized as a dynamic place where critical cell interactions occur and play an important role in altering tumorigenesis. While many studies have investigated the effects of cellular cross-talk within distinct tumor microenvironments, these interactions have yet to be fully examined in bone. It is well-established that many common cancers metastasize to bone, resulting in the development of tumor-induced bone disease (TIBD), a multi-facetted illness that is driven by complex cell interactions within the bone marrow.
Source: Bone - Category: Orthopaedics Authors: Tags: Full Length Article Source Type: research