TRIM38 regulates NF- κB activation through TAB2 degradation in osteoclast and osteoblast differentiation

In this study, we report the involvement of TRIM38 in osteoclast and osteoblast differentiation. Overexpression of TRIM38, in osteoclast precursor cells, attenuated receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclast formation, RANKL-triggered NF- κB activation, and expression of osteoclast marker genes, such as NFATc1, osteoclast-associated receptor (OSCAR), and tartrate-resistant acid phosphatase (TRAP); and down-regulation of TRIM38 expression showed the opposite effects.

Source: Bone - May 10, 2018 Category: Orthopaedics Authors: Kabsun Kim, Jung Ha Kim, Inyoung Kim, Semun Seong, Nacksung Kim Tags: Full Length Article Source Type: research