Radiation-induced ovarian follicle loss occurs without overt stromal changes

We examined stromal quality using histologic stains to visualize ovarian architecture and fibrosis and by immunohistochemistry and quantitative microscopy to assess cell proliferation, cell death and vasculature. There were no differences in the ovarian stroma across cohorts with respect to these markers, indicating that this compartment is more radio-resistant relative to the germ cells. These findings have implications for reproductive health and the field of fertility preservation because the radiation doses we examined mimic scatter doses experienced in typical therapeutic regimens.

Source: Reproduction - May 10, 2018 Category: Reproduction Medicine Authors: Kimler, B. F., Briley, S. M., Johnson, B. W., Armstrong, A. G., Jasti, S., Duncan, F. E. Tags: Research Source Type: research