Genetic Regulation of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Plasma Levels and Its Impact on Atherosclerotic Vascular Disease Phenotypes [Original Articles]

Conclusions:
Variants at the PCSK9 gene locus seem to be the major genetic determinants of plasma PCSK9 levels with 4 independent variants at the PCSK9 gene locus expressing allelic heterogeneity. The detected MR estimates support the hypothesis of a causal effect of PCSK9 on coronary artery disease and other vascular phenotypes. Other observed genetic associations for PCSK9 require validation in independent cohorts.

Clinical Trial Registration:
URL: http://www.clinicaltrials.gov. Unique Identifier: NCT00497887.

Source: Circulation: Cardiovascular Genetics - May 10, 2018 Category: Cardiology Authors: Pott, J., Schlegel, V., Teren, A., Horn, K., Kirsten, H., Bluecher, C., Kratzsch, J., Loeffler, M., Thiery, J., Burkhardt, R., Scholz, M. Tags: Lipids and Cholesterol, Genetic, Association Studies, Atherosclerosis Original Articles Source Type: research