The impact of age on radium-223 distribution and an evaluation of molecular imaging surrogates

Radium-223 dichloride is the first alpha-particle emitting therapeutic agent approved by FDA and EMA for bone metastatic castration-resistant prostate cancer. We studied its age-dependent biodistribution in mice, and compared it with [99mTc]Tc-MDP and [18F]NaF aiming to identify a potential imaging surrogate to predict [223Ra]RaCl2 whole-body localization.
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Source Type: research