Influences of the T102C polymorphism in the 5-HT2A receptor gene on the five-factor model of Positive and Negative Syndrome Scale and treatment response to aripiprazole in patients with acute schizophrenia
Because second-generation antipsychotics inhibit dopamine D2 receptors and serotonin (5-HT) 2A receptors, genetic studies have focused on these genes (Chen et al., 2009; Miura et al. 2012). Pharmacogenetic studies have investigated the association between the 5-HTR2A gene (HTR2A) and antipsychotic treatment response (Chen et al., 2009; Olajossy-Hilkesberger et al. 2011); however, the results were inconclusive. The T102C polymorphism (rs6313) of HTR2A is located in the first exon and causes no amino acid substitution and is not thought to be a functional polymorphism.
Source: Psychiatry Research - Category: Psychiatry Authors: Keiko Kanno-Nozaki, Itaru Miura, Haruka Kaneko, Sho Horikoshi, Takafumi Ota, Michinari Nozaki, Hiroki Ejiri, Mitsuharu Yahiro, Kenya Watanabe, Mizuki Hino, Hirooki Yabe Source Type: research