Variants in ZNF804A and DTNBP1 assessed for cognitive impairment in schizophrenia using a multiplex family-based approach

The most affected domains of cognitive impairment in schizophrenia are working memory, attention, verbal learning, visual learning, reasoning, problem solving, speed of processing, and social cognition. There are shared genetic effects between schizophrenia and cognitive impairment. Zinc finger protein 804A (ZNF804A) and dystrobrevin binding protein 1 (DTNBP1), had been reported as links to both schizophrenia and cognitive deficit (Burdick et al., 2006; Pae et al., 2009). Therefore, the current study utilized a multiplex family-based case-control sample to investigate associations between variants of ZNF804A and DTNBP1 cognitive deficits in schizophrenia.

Source: Psychiatry Research - May 7, 2018 Category: Psychiatry Authors: Tze Jen Chow, Shiau Foon Tee, Siew Yim Loh, Hoi Sen Yong, Abdul Kadir Abu Bakar, Pek Yee Tang Source Type: research