Transcriptional analysis reveals the critical role of RNA polymerase-binding transcription factor, DksA, in regulating multi-drug resistance of Escherichia coli

The uncontrolled use of antibiotics in medicine and agriculture has resulted in the extensive antibiotic-resistant bacteria, antibiotic resistance genes (ARGs), and detection of antibiotics in the environment worldwide. Especially concerning is the continued emergence of “superbugs” and untreatable infections. The Gram-negative bacterium Escherichia coli is a common intestinal microorganism of humans and animals [1]. The incidence of antimicrobial-resistant E. coli infections is increasing globally [2–4].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research