Immunophenotypic analysis of the chronological events of tissue repair in aortic medial dissections

Acute medial dissection of aorta can occur in the context of a sudden and unexpected death. For medico-legal reasons it is important to estimate as accurately the histological age of dissections. We evaluated the additional value of a systematic application of immunohistochemistry, compared with conventional histology only, in determining chronological steps of injury and repair. Thirty two paraffin embedded specimens of aortic dissection were retrospectively allocated to one of four defined stages: acute (I), subacute (II), early organizing (III) and scarring (IV) using Hematoxylin and Eosin and Elastica van Gieson stained sections.

Source: Cardiovascular Pathology - February 10, 2018 Category: Cardiology Authors: Silvia D. Vison à, Onno J. de Boer, Claire Mackaaij, Hans H. de Boer, Kartika R. Pertiwi, Ruben W. de Winter, Antonio Osculati, Allard C. van der Wal Tags: Original Article Source Type: research