Aspartate beta-hydroxylase promotes cholangiocarcinoma progression by modulating RB1 phosphorylation

Cholangiocarcinoma (CCA) is a highly lethal and aggressive disease. Recently, IDH1/2 mutations have been identified in approximately 20% of CCAs which suggests an involvement of 2-oxoglutarate (2-OG) -dependent dioxygenases in oncogenesis. We investigated if the 2-OG dependent dioxygenase, aspartate beta-hydroxylase (ASPH) was important in tumor development and growth. Immunoassays were used to clarify how ASPH modulates CCA progression by promoting phosphorylation of the retinoblastoma protein (RB1).

Source: Cancer Letters - May 4, 2018 Category: Cancer & Oncology Authors: Chiung-Kuei Huang, Yoshifumi Iwagami, Jing Zou, Sarah Casulli, Shaolei Lu, Katsuya Nagaoka, Chengcheng Ji, Kousuke Ogawa, Kevin Y. Cao, Jin-Song Gao, Rolf I. Carlson, Jack R. Wands Tags: Original Articles Source Type: research