Relationships between human cortical bone toughness and collagen cross-links on paired anatomical locations

Human cortical bone fracture processes depend on the internal porosity network down to the lacunar length scale. Recent results show that at the collagen scale, the maturation of collagen cross-links may have a negative influence on bone mechanical behavior. While the effect of pentosidine on human cortical bone toughness has been studied, the influence of mature and immature enzymatic cross-links has only been studied in relation to strength and work of fracture. Moreover, these relationships have not been studied on different paired anatomical locations.

Source: Bone - May 3, 2018 Category: Orthopaedics Authors: R émy Gauthier, Hélène Follet, Max Langer, Evelyne Gineyts, Frédéric Rongiéras, Françoise Peyrin, David Mitton Tags: Full Length Article Source Type: research