Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma

Constitutive activation of the phosphoinositide 3-kinase/AKT signalling pathway is frequently observed in high-grade gliomas with high frequency of losing PTEN tumour suppressor. To identify transcriptomic profiles associated with a hyperactivated PI3K pathway, RNA-sequencing analysis was performed in a glioblastoma cell line stably expressing PTEN. RNA-sequencing revealed enriched transcripts of pro-inflammatory mediators, and among the genes that displayed highly differentially expression was the secreted glycoprotein YKL-40.

Source: Cancer Letters - May 3, 2018 Category: Cancer & Oncology Authors: Yubing Wang, Chi-Wai Wong, Mingfei Yan, Lisha Li, Tian Liu, Penelope Mei-Yu Or, Stephen Kwok-Wing Tsui, Mary Miu-Yee Waye, Andrew Man-Lok Chan Tags: Original Articles Source Type: research