Tacrolimus-Induced Apoptosis is Mediated by Endoplasmic Reticulum –derived Calcium-dependent Caspases-3,-12 in Jurkat Cells

We examined the effect of tacrolimus on ER-derived calcium and caspase-3,-12–mediated apoptosis on Jurkat human T lymphocyte. Tac decreased the viability of Jurkat cells in a dose-dependent manner.

Source: Transplantation Proceedings - May 1, 2018 Category: Transplant Surgery Authors: Y.W. Chung, M.W. Chung, S.K. Choi, S.J. Choi, S.J.N. Choi, S.Y. Chung Tags: Asian Transplantation Week 2017 Source Type: research