Combining chloroquine with RAD001 inhibits tumor growth in a NEN mouse model

In conclusion, CQ enhances the anti-tumorigenic effect of RAD001 in vivo by inhibiting autophagy. Clinical trials addressing the effects of CQ therapy on neoplasm progression in patients with NENs, mainly in those treated with mTORi, are warranted.

Source: Endocrine-Related Cancer - May 3, 2018 Category: Endocrinology Authors: Avniel-Polak, S., Leibowitz, G., Doviner, V., Gross, D. J., Grozinsky-Glasberg, S. Tags: Research Source Type: research