Effect of Hepatic Preconditioning with the Use of Methylene Blue on the Liver of Wistar Rats Submitted to Ischemia and Reperfusion

The liver may be injured in situations where it is submitted to ischemia, such as partial hepatectomy and liver transplantation. In all cases, ischemia is followed by reperfusion and, although it is essential for the reestablishment of tissue function, reperfusion may cause greater damage than ischemia, an injury characterized as ischemia-reperfusion (I/R) damage. The aim of this work was to analyze the effect of ischemic preconditioning with the use of methylene blue (MB; 15 mg/kg) 5 or 15 minutes before I/R (IRMB5 ′ and IRMB15′, respectively) on the hepatic injury occurring after I/R.

Source: Transplantation Proceedings - April 1, 2018 Category: Transplant Surgery Authors: T.N. de Almeida, J.P. Victorino, J. Bistafa Liu, D. T ófoli Queiroz Campos, C. Graf, M.C. Jordani, L.A. Carneiro d'Albuquerque, K.D.S. Mendes, O. Castro-e-Silva Tags: 15th Brazilian Transplantation Congress and 16th Portuguese-Brazilian Transplantation Congress Source Type: research