Correlation between percentage of immuncompetent CD4+ and CD4+CD25+ cells and compatibility in the HLA system and selected parameters assessing transplanted kidney function

Long-term kidney allograft survival is affected by many coexisting immunologic factors. Currently, only two basic immunologic parameters: HLA compatibility and panel reactive antibodies are routinely used in kidney transplantation management. At the same time there is a great need for immunologic biomarkers which will help understand kidney transplant immunology and improve clinical care over kidney recipients. T regulatory cells (Tregs)represent one of the major targets of this approach. The aim of this study was to investigate possibile simple associations between Tregs count in recipients ’ blood and other routinely assessed or easily approachable laboratory parameters.
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Source Type: research