Treatment resistance in urothelial carcinoma: an evolutionary perspective

Treatment resistance in urothelial carcinoma: an evolutionary perspectiveTreatment resistance in urothelial carcinoma: an evolutionary perspective, Published online: 02 May 2018; doi:10.1038/s41571-018-0026-yPatients with advanced-stage urothelial carcinoma typically receive chemotherapy and might also receive immune-checkpoint inhibitorsfollowing disease progression. However, the majority of patients will ultimately develop resistance to treatment. In this Review, the authors describe the evolutionary mechanisms of treatment resistance in patients with urothelial carcinoma.
Source: Nature Clinical Practice Oncology - Category: Cancer & Oncology Authors: Source Type: research