Clonality analysis of multifocal ipsilateral breast carcinomas using X-chromosome inactivation patterns
The definition of multifocal breast cancer is ambiguous, and its incidence varies depending on the definition and detection methods. Multifocal breast cancers either have the same clonal origin or arise from completely distinct progenitor cells. The current American Joint Committee on Cancer Staging system and College of American Pathologists breast tumor guidelines state that only the largest tumor needs to be staged and studied immunohistochemically, on the assumption that they are of the same origin.
Source: Human Pathology - Category: Pathology Authors: Hayeon Kim, Chung-Yeul Kim, Kyong Hwa Park, Aeree Kim Source Type: research