Treatment of toxic epidermal necrolysis by a multidisciplinary team. A review of literature and treatment results

Toxic Epidermal Necrolysis (TEN) is a severe cutaneous reaction to drugs or their metabolites with multisystem involvements. The mortality rate is approximately 30% [1]. The incidence is reported to be 1 –2 per million [2,3]. Pathogenesis is largely unknown, but involves an inappropriate immune response leading to apoptosis of keratinocytes causing separation at the dermoepidermal junction. This results in bullae and epidermal sloughing. The reaction can occur in all age groups but the risk is enh anced in the setting of immunosuppression (HIV, SLE, Collagen Vascular Disease, and malignancy) [3,4].
Source: Burns : Journal of the International Society for Burn Injuries - Category: Cosmetic Surgery Authors: Source Type: research