Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression

As the most well-known circular RNA, ciRS-7 (also termed CDR1as) has been reported to act as a miR-7 sponge, resulting in reduced miR-7 activity and increased miR-7-targeted transcripts. Here, we showed that ciRS-7 is up-regulated in esophageal squamous cell carcinoma (ESCC), and is associated with the poor clinicopathological parameters of ESCC patients. Moreover, over-expression of ciRS-7 increased the proliferation, migration and invasion of ESCC cells. Mechanistic studies revealed that ciRS-7 contains nineteen miR-876-5p binding sites and acts as a miR-876-5p sponge.

Source: Cancer Letters - April 7, 2018 Category: Cancer & Oncology Authors: Meixiang Sang, Lingjiao Meng, Yang Sang, Shina Liu, Pingan Ding, Yingchao Ju, Fei Liu, Lina Gu, Yishui Lian, Juan Li, Yunyan Wu, Xiaochong Zhang, Baoen Shan Tags: Original Articles Source Type: research