Delayed return to estrus following treatment with the gonadotrophin-releasing hormone agonist, Lucrin ® Depot, in the tammar wallaby

Gonadotrophin-releasing hormone agonists that induce a reversible contraceptive state in several marsupials have the potential to be used to synchronize estrus. We used a model macropod, the tammar wallaby (Notamacropus eugenii), to investigate whether Lucrin Depot (AbbVie), a GnRH agonist microsphere preparation, could (1) inhibit follicular development and estrus in a cycle reactivated by removal of pouch young (RPY) and (2) facilitate a synchronous return to estrus. Our results show that females reactivated with bromocriptine and RPY in early seasonal quiescence (July 2015) were inhibited by Lucrin Depot (0.125 –0.5 mg kg −1, n = 9) and unlike control females (n = 3), did not copulate before Day 32 RPY.

Source: Theriogenology - April 30, 2018 Category: Genetics & Stem Cells Authors: Ryan R. Witt, Lyn A. Hinds, John C. Rodger Source Type: research