Impact of baseline CO2 on Blood-Oxygenation-Level-Dependent MRI measurements of cerebrovascular reactivity and task-evoked signal activation

Neurovascular coupling describes the cascade between neuronal activity and subsequent Blood-Oxygenation-Level-Dependent (BOLD) signal increase.Based on this premise, the correlation of this BOLD signal increase with a particular task, such as finger-tapping, is used to map neuronal activation. This signal increase may be dampened in brain areas exhibiting impaired cerebrovascular reactivity (BOLD-CVR), leading to false negative activation. Blood-oxygenation-level-dependent (BOLD) cerebrovascular reactivity (CVR) has also been used to optimize task evoked BOLD signal changes.

Source: Magnetic Resonance Imaging - February 13, 2018 Category: Radiology Authors: Christiaan Hendrik Bas van Niftrik, Marco Piccirelli, Oliver Bozinov, Nicolai Maldaner, Catherine Strittmatter, Athina Pangalu, Antonios Valavanis, Luca Regli, Jorn Fierstra Source Type: research