TGFβ and Wnt in Cardiac Outflow Tract Defects in Offspring of Diabetic Pregnancies

CONCLUSIONSMaternal diabetes generates oxidative and ER stress conditions, suppresses TGFβ and Wnt signaling, inhibits cell proliferation and cellularization of the endocardial cushions, leading to OFT septal defects. Activin‐A plays a role in hyperglycemia‐suppressed proliferation of the endocardial cells

Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - September 17, 2014 Category: Perinatology & Neonatology Authors: Zhiyong Zhao Tags: Research Article Source Type: research