Increased sensorimotor network connectivity associated with clozapine eligibility in people with schizophrenia

Schizophrenia is a heterogeneous disorder that exhibits variable responsiveness to treatment between individuals. Here we conducted a resting-state functional magnetic resonance imaging (rs-fMRI) study to determine whether resistance to first-line antipsychotics is reflected in resting-state connectivity. rs-fMRI data were collected from 15 people who had failed to respond to first-line antipsychotics (clozapine-eligible) and 10 first-line treatment responders (FLR). Image pre-processing and analysis were performed using FMRIB's software library (FSL).

Source: Psychiatry Research: Neuroimaging - February 28, 2018 Category: Psychiatry Authors: Carolyn Beth McNabb, Frederick Sundram, Ian Soosay, Robert R. Kydd, Bruce Roy Russell Source Type: research