Striatal changes in Parkinson disease: An investigation of morphology, functional connectivity and their relationship to clinical symptoms

We sought to investigate morphological and resting state functional connectivity changes to the striatal nuclei in Parkinson disease (PD) and examine whether changes were associated with measures of clinical function. Striatal nuclei were manually segmented on 3T-T1 weighted MRI scans of 74 PD participants and 27 control subjects, quantitatively analysed for volume, shape and also functional connectivity using functional MRI data. Bilateral caudate nuclei and putamen volumes were significantly reduced in the PD cohort compared to controls.

Source: Psychiatry Research: Neuroimaging - March 7, 2018 Category: Psychiatry Authors: Conor Owens-Walton, David Jakabek, Xiaozhen Li, Fiona A. Wilkes, Mark Walterfang, Dennis Velakoulis, Danielle van Westen, Jeffrey C.L. Looi, Oskar Hansson Source Type: research