Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers

Circadian rhythm disturbances are common in bipolar affective disorder (BD). Delayed sleep-wake phase syndrome (DSWPD) is the most prevalent circadian rhythm sleep-wake disorder (CRSWDs) and is frequently observed in BD. It is unclear whether DSWPD in BD is an independent process or is a consequence of BD. In this hypothetical review, we discuss the overlap between BD and DSWPD and potential common biomarkers for DSWPD and BD. The review will include a discussion of the genetics of DSWPD and BD.

Source: Sleep Medicine Reviews - February 13, 2018 Category: Sleep Medicine Authors: Farid Talih, Nour Y. Gebara, Farah S. Andary, Stefania Mondello, Firas Kobeissy, Raffaele Ferri Tags: Theoretical Review Source Type: research