The putative role of Oxidative Stress and Inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on Chronic Fatigue Syndrome, Bipolar Disorder and Multiple Sclerosis
Sleep and circadian abnormalities are prevalent and burdensome manifestations of diverse neuro-immune diseases, and may aggravate the course of several neuropsychiatric disorders. The underlying pathophysiology of sleep abnormalities across neuropsychiatric disorders remains unclear, and may involve the inter-play of several clinical variables and mechanistic pathways. In this review, we propose a heuristic framework in which reciprocal interactions of immune, oxidative and nitrosative stress, and mitochondrial pathways may drive sleep abnormalities across potentially neuroprogressive disorders.
Source: Sleep Medicine Reviews - Category: Sleep Medicine Authors: Gerwyn Morris, Brendon Stubbs, Cristiano A. K öhler, Ken Walder, Anastasiya Slyepchenko, Michael Berk, André F. Carvalho Tags: Theoretical Review Source Type: research
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