Co-targeting of BET proteins and HDACs as a novel approach to trigger apoptosis in rhabdomyosarcoma cells

Histone acetylation marks exert essential functions in regulating gene expression. These marks are written by histone acetyltransferases (HATs), removed by histone deacetylases (HDACs) and read by e.g. BET proteins. While BET inhibitors are promising new anticancer drugs, little is yet known on their antitumor activity in rhabdomyosarcoma (RMS). We therefore investigated the efficacy of the prototypic BET inhibitor JQ1 alone or in combination with other epigenetic modifiers, namely HDAC inhibitors (HDACIs).

Source: Cancer Letters - April 27, 2018 Category: Cancer & Oncology Authors: Julius C. En ßle, Cathinka Boedicker, Marek Wanior, Meike Vogler, Stefan Knapp, Simone Fulda Tags: Original Articles Source Type: research